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Open access Aug 2026

TUDCA was identified as a potential therapeutic drug for nonalcoholic steatohepatitis complicated with hypercholesterolemia targeting ADRA2C by integrated bioinformatics and experimental verification

Nonalcoholic steatohepatitis (NASH) is a type of liver disease in which fat accumulates in the liver with inflammation. Hypercholesterolemia is a common autosomal dominant inherited metabolic disease. Previous studies have suggested a potential association between NASH and hypercholesterolemia, but the pathophysiolog...

Hongfeng Liu, Yuxiao Fan, Zhanpeng Sun et al. · 0 citations

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