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Author

Q. Zhang

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Open access Oct 2026

Resolving cell–cell interaction networks and their molecular logic in complex tissues

CCI-seq identified known interactions and fine-grained cellular organization in mouse kidney and intestine, and uncovered aberrant interactions and disrupted spatial organization in adenomatous polyposis coli knockout (Apc-KO) intestines, and revealed subtype-specific interactions linked to clinical classifications.

Lei Tang, Kang Tian, Xiao-Lei Fu et al. · 0 citations
Open access Oct 2026

DeCoRE: A computational method to resolve RNA structural heterogeneity from RNA structure probing data by direct RNA sequencing

RNA molecules are inherently dynamic, forming complex structural ensembles of alternative conformations that direct their cellular functions. Current methods for resolving RNA structural heterogeneity and dynamics have been developed for short-read sequencing–based structure probing, limiting their sensitivity and reso...

Yong Huang, Jin-Song Zhang, Lei Sun et al. · 0 citations
Open access Jul 2026

Spaceflight multi-omics reveals vulnerabilities of human germ cell development

An automated bioreactor was utilized that supported long-term differentiation of human embryonic stem cells into human induced primordial germ cells, human induced ovarian follicles, and human induced spermatogonial stem cells aboard spacecraft and demonstrated preserved genomic integrity despite these functional pertu...

Ying Li, Hui Gao, Jie Xiong et al. · 0 citations

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