Drug resistance remains a major barrier to durable targeted therapy, and cancer progression often reflects rewiring of signalling pathways that control protein stability. Dysregulation of the ubiquitin–proteasome system, including failure of degron-dependent substrate recognition, can stabilise oncogenic proteins, acce...
Jia-Xin Li, Shu-Han Liu, Lu Fu et al.· Frontiers in Cell and Develo...· 0 citations
OTU deubiquitinase with linear linkage specificity (OTULIN) is the only deubiquitinase known to exhibit strict specificity for Met1-linked linear ubiquitin chains, serving as a critical regulator that restrains linear ubiquitin chain assembly complex and maintains inflammatory homeostasis and tissue integrity. Advances...
Ziyu Zhang, Jiahang Lyu, Yujie Bai et al.· Frontiers in Immunology· 0 citations
This study is the first to integrate a multidimensional visual analysis of the knowledge landscape in tumor microenvironment and immune escape research, highlighting the translational potential of combined therapeutic strategies targeting TME-immune interactions.
Xinyu Feng, Xiu-Mei Sun, Han Bi et al.· Medicine· 0 citations
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