Converting Nonspecific Adsorption into Bioaffinity Recognition: Defect-Engineered MOF-808 Creates a Synergistic Enzyme Interface for Selective Ligand Fishing and Closed-Loop Target Confirmation
Nonspecific adsorption of metal −organic frameworks (MOFs) limits the analytical reliability of immobilized-enzyme ligand fishing in complex natural systems. In this work, an activity-guided defect-engineering strategy was developed to convert MOF-808 into a synergistic enzyme-MOF biointerface for selective molecular...