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Author

Qi Liu

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Review Open access Oct 2026

Cartilage Extracellular Matrix Homeostasis in Knee Osteoarthritis: Pathomechanisms and Therapeutic Targeting

Knee osteoarthritis (KOA) is a degenerative joint disease primarily driven by the disruption of homeostasis in the chondrocyte extracellular matrix (CECM). This review systematically examines the central role of CECM homeostasis in KOA pathogenesis and summarizes recent advances in this field. We synthesized contempora...

Chao Du, Ji-Wei Zhong, Jia-Lin Yang et al. · 0 citations
Review Open access Oct 2026

Pharmacological regulation of chondrocyte ferroptosis by plant-derived metabolites in osteoarthritis: from molecular mechanisms to targeted nanodelivery

Osteoarthritis (OA) lacks approved disease-modifying pharmacotherapy. Chondrocyte ferroptosis—iron-dependent phospholipid peroxidation caused by disrupted iron handling, lipid metabolism, and antioxidant defense—has been implicated in cartilage degeneration and is pharmacologically suppressible in experimental models....

Tian-Ci Guo, Qi Liu, Ji-Da Wang et al. · 0 citations

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