Locus coeruleus-spinal noradrenergic signaling drives sleep deprivation-induced hyperalgesia via astrocytic GAT-3.
Sleep deprivation is a prevalent health problem that amplifies pain and prolongs recovery after tissue injury, yet the neural and astrocytic mechanisms underlying this relationship remain poorly defined. Here, we demonstrate that sleep deprivation activates locus coeruleus noradrenergic neurons and elevates spinal nore...