A nutrient-sensing protease DegS suppresses biofilm formation in Vibrio cholerae via the CdgH–c-di-GMP–VpsR axis under nutrient limitation
The transition of Vibrio cholerae from the host intestine to oligotrophic aquatic environments presents a severe nutrient downshift, yet the upstream sensory mechanism that triggers adaptive biofilm formation remains unclear. Here, we identify the periplasmic protease DegS as a critical nutrient-responsive regulator th...