Open access
Aug 2026
Metabolomics and Machine Learning Uncover 5′-Methylthioadenosine as a Metabolic Indicator of Mixed-Pattern Drug-Induced Liver Injury
MTA emerges as an exploratory biomarker that uncovers the distinct metabolic trajectories hidden within mixed-pattern DILI, and these findings highlight the MTA-methylthioadenosine phosphorylase phosphorylase (MTAP) axis as a potential mechanistic driver of cholestatic injury.
Jing-Hui Zhang, Hong-Chuan Liu, Qi Qiu et al.
· Metabolites · 0 citations