Branched-chain amino acids (BCAAs) are recognized not only as industrially important fermentation products but also as versatile biosynthetic platforms for the production of branched-chain value-added chemicals. The characteristic branched carbon skeletons of BCAAs, together with their metabolically versatile intermedi...
Rong-Lin Lai, Qi Sheng, Ming Huang et al.· Biotechnology Advances· 0 citations
An enzyme-constrained model was used to identify 11 gene targets affecting l-arginine production and engineered the rate-limiting enzyme argininosuccinate synthetase to construct the strain Arg11, achieving the best performance reported to date.
Shengyang He, Qi Sheng, Gang Men et al.· Bioresource Technology· 0 citations
Cryogenic-electron microscopy structures of human NLRP6 monomer in the adenosine-5'-triphosphate (ATP)/NBD-bound (twisted conformation) and unbound (extended conformation) states reveal the ATP-mediated cooperative inhibition mechanism of NLRP6 and provide insight into the therapeutic intervention of NLRP6-related auto...
Zhen Cui, Qi Sheng, Minsoo Son et al.· Nature Structural & Molecula...· 0 citations
L-Isoleucine is an essential branched-chain amino acid for livestock and poultry, supporting protein accretion and regulating energy metabolism, immune function, and stress resilience. A genetically stable L-isoleucine producer, Corynebacterium glutamicum cgl-Ile0, was obtained via biosensor-assisted ARTP mutagenesis,...
Junkun Cao, Ming Huang, Qi Sheng et al.· Journal of Animal Science an...· 0 citations
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