Open access
Sep 2026
Disruption of CTCF-mediated IGF2 repression promotes AKT-dependent mitochondrial oxidative stress and chondrocyte senescence in osteoarthritis.
Findings support a functional regulatory framework linking CTCF-IGF2 dysregulation with AKT-dependent mitochondrial oxidative stress and chondrocyte senescence in OA, highlighting IGF2 signaling as a potential therapeutic target.
Chun-Pan Zhang, Fei Xu, Jiang-Ping Wu et al.
· Life Science · 0 citations