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Review Open access Oct 2026

Tumor Microenvironment-Responsive Smart Nanodrug Delivery Systems for Cancer Theranostics

Acidity, hypoxia, redox imbalance, and altered enzyme activity in the tumor microenvironment (TME) can be used to regulate nanocarrier structure and drug release. However, these conditions vary among tumors and across regions within individual tumors and overlap with certain normal physiological and inflammatory proces...

Xiu-Lin Wen, Yong-Xin Jiang, Han-Jing Yang et al. · 0 citations
Sep 2026

A Theranostic Nanozyme for Osteoarthritis Treatment and Glycosaminoglycan-Targeted Diagnosis of Cartilage Pathology

The lack of vascular and neural innervations in cartilage often results in poor drug delivery and penetration, compromising the efficacy of current therapeutics. To tackle this clinical challenge, we designed positively charged manganese-doped CeO2 nanozymes that combine reactive oxygen species (ROS)-scavenging activ...

Dong-Ze Mo, Yan-Bing Wen, Chao-Qun Cheng et al. · 0 citations

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