To overcome inadequate tumor immunogenicity and the immunosuppressive tumor microenvironment, a self-assembled nanomedicine (R848@FSQ) is developed by coordinating the chemotherapeutic drugs shikonin (SHK) and quercetin (Qu) with Fe3 + to form a metal-phenolic network (MPN), and is simultaneously loaded with the immune...
Xing-Xing Peng, Qi-Wen Chen, Jing Chang et al.· Colloids and Surfaces B: Bio...· 0 citations
Lung cancer therapy is severely hindered by the pulmonary mucus barrier and chemotherapy resistance driven by therapy-induced senescence (TIS) following DNA-damaging agents. Herein, we report an inhalable, mucus-penetrating nanoliposomes (DR@DPPC-Apt) engineered by incorporating an L1 cell adhesion molecule (L1CAM)-tar...
Yun-Qi Man, Yan-Fei Liu, Yong-Bo Liu et al.· Biomaterials· 0 citations
Tumor immunotherapy has transformed modern oncology, yet its clinical efficacy against solid tumors remains severely restricted by complex physiological and immunosuppressive barriers. Distinct from passive delivery systems, live bacteria can actively navigate into hypoxic tumor cores and intrinsically modulate local i...
Jun-Jie Wu, Li-Shang Xu, Qi-Wen Chen et al.· Journal of Controlled Releas...· 0 citations
This review systematically maps the molecular architecture of the senescent-cell heterogeneity, off-target toxicity, and the lack of standardized biomarkers, and provides a framework for developing precision strategies to detect, modulate, or eliminate senescent cells in a context-appropriate manner.
Ze-Xiang Lv, Yan-Fei Liu, Yong-Bo Liu et al.· ACS Biomaterials Science & E...· 0 citations
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