Author

Qi-Yun Liang

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Open access Sep 2026

Evolutionary and structural pathways of antibody maturation reveal principles for engineering potent SARS-CoV-2 neutralizers

The continual emergence of SARS-CoV-2 variants underscores the need to elucidate antibody maturation and apply rational design principles to optimize therapeutics. This study focused on vaccine-elicited 9C lineage, encoded by IGHV4–34, as a model for affinity maturation and structural refinement. Sequence analyses reve...

Muhammad Waqas Nasir, Qi-Yun Liang, Jing Wang et al. · Journal of Structural Biolog... · 0 citations

Open access Sep 2026

Establishment of a rapid detection method for severe fever with thrombocytopenia syndrome virus based on reverse transcription-recombinase polymerase amplification with lateral flow nucleic acid chromatography assay technology

Introduction Severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus associated with febrile illness, thrombocytopenia, and leukopenia, represents a considerable public health threat. Methods In this study, we developed a visual detection platform for SFTSV by integrating reverse transcription-rec...

Zhou-Jie Ma, Yong-Chuan Gan, Qi-Yun Liang et al. · Frontiers in Microbiology · 0 citations

Open access Aug 2026

Allosteric effects of CDR-H3 mutations modulate binding and neutralization of a conserved SARS-CoV-2 RBD-targeting antibody

Comparing wild-type XG83 and modified MuXG83 shows how allosteric tuning affects antibody-antigen compatibility in developing variations like Omicron, and indicates that non-epitope (potentially allosteric) changes to CDRH3 are also important while investigating potential development and neutralization before advanceme...

Muhammad Waqas Nasir, Qi-Yun Liang, Jun He et al. · Microbiology spectrum · 0 citations