Radical S-adenosylmethionine (rSAM) enzymes constitute one of the largest and most versatile enzyme superfamilies in biology, catalyzing diverse radical-mediated reactions essential for metabolism, cofactor biosynthesis, nucleic acid modification, and natural product formation. Central to their chemistry is the reducti...
Xu-Xue Liu, Xiang-Yang Gao, Sasipa Booranamonthol et al.· RSC Chemical Biology· 0 citations
Nucleoside analogues are important therapeutic scaffolds, but their synthesis is often protecting-group-intensive. Purine nucleoside phosphorylases offer a mild enzymatic alternative, yet broad substrate accommodation does not necessarily lead to productive glycosyl transfer. Here, we repurposed HpnG, a hopanoid-asso...
Xu-Xue Liu, De Yang, Rung-Yi Lai et al.· Organic Letters· 0 citations
Unlike the antimicrobial darobactin, aphotorhaptin A appears to lack antibacterial activity but modulates nematode development, and this activity requires the ether crosslink and the N-terminal acetyl group in the hexapeptide scaffold.
Suze Ma, Ru Li, Xiang-Yang Gao et al.· Proceedings of the National...· 0 citations
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