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Review Open access Oct 2026

Follicular development impairment in polyendocrine metabolic ovarian syndrome: multidimensional pathophysiological networks and frontier therapeutic targets

Polyendocrine metabolic ovarian syndrome (PMOS) is a prevalent endocrine-metabolic disorder characterised by follicular arrest, anovulation, and elevated androgen levels. This review transcends single-dimensional analyses of PMOS pathology from neuroendocrine or metabolic perspectives, proposing an integrated multi-lay...

Qiu-Cheng Jia, Shu-Li Zhang, Li-Xing Zhang et al. · 0 citations
Open access Sep 2026

Lipotoxicity-induced ER-mitochondrial hypercoupling activates the mtDNA-cGAS-STING-NF-κB axis to drive follicular arrest in metabolically compromised PCOS

Melatonin emerged as a superior therapeutic candidate, preserving organelle architecture, preventing calcium dysregulation, blocking mtDNA release, and attenuating inflammation both in vitro and in a PCOS mouse model, and position melatonin as a clinically translatable therapeutic agent for rescuing follicular developm...

Ming-Rui Xue, Qi Zhu, Shu-Li Zhang et al. · 0 citations

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