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Author

Qian Cheng

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2 papers indexed here

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Open access Aug 2026

Therapeutic potential and underlying mechanisms of engineered young plasma-derived exosomes in Alzheimer's disease

The potential value of young plasma-derived EXOs in AD treatment is revealed for the first time and, through RVG engineering strategies and the elucidation of the RPTOR-autophagy mechanism, provides new insights for targeted therapy of neurodegenerative diseases.

Hang Chen, Yuanquan Si, Qian Cheng et al. · 0 citations
Open access Jul 2026

CAPNS1 restoration partially alleviates mitochondrial dysfunction and synaptic deficits in Alzheimer's disease through the Ca2⁺-CaMKIIβ-MAPK-PGC-1α axis.

Significantly, neuronal-specific CAPNS1 upregulation in APP/PS1 transgenic mice markedly improved mitochondrial cristae integrity, reversed hippocampal long-term potentiation deficits, increased dendritic spine density, and partially alleviated spatial memory deficits in behavioral tests.

Jia-Lin Han, Shuang Wu, Xiaolin Cui et al. · 0 citations

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