Author

Qiancheng Zhao

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Open access Oct 2026

Macrophage pyroptosis drives luminal senescence and club-cell reprogramming in 5α-reductase inhibitor-treated prostatic hyperplasia.

Benign prostatic hyperplasia (BPH) is a common age-associated disease whose prevalence rises sharply with advancing age. Therapeutic responses to 5α-reductase inhibitors (5-ARIs) in BPH are heterogeneous and may ultimately culminate in the need for surgery; however, the mechanisms that permit disease progression during...

Zheng Li, Zhe-Nan Zhang, Qian-Cheng Zhao et al. · Experimental and Molecular M... · 0 citations

Open access Sep 2026

Longitudinal gut microbiome dynamics during immunotherapy identify microbial features of clinical benefit in advanced primary liver cancer.

BACKGROUND The gut microbiome has been linked to immune checkpoint inhibitor (ICI) outcomes, but the temporal dynamics of microbial communities during treatment remain poorly characterised. OBJECTIVE To characterise gut microbiome trajectories during ICI therapy and evaluate whether on-treatment microbial states impr...

Zhen-Wei Qian, Jie Han, Beile Lyu et al. · Gut · 0 citations