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Author

Qian-Fei Zuo

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Sep 2026

TIGIT regulates CD8+T cell exhaustion via the PI3K/AKT-FOXO1-TOX axis in extrahepatic cholangiocarcinoma.

Extrahepatic cholangiocarcinoma (ECCA) is an aggressive malignancy with poor prognosis and few treatment options, partly due to CD8+T cell exhaustion in the tumor microenvironment. The role of TIGIT in driving this process remains mechanistically unclear. Using patient-derived immunocompetent cultures (iPDCs), we show...

Rui-Heng Luo, Ling Li, De-Hong Tan et al. · 0 citations

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