Hydroxyethyl starch serves as a superior vehicle for colon-targeted delivery of indole-3-acetic acid to enhance therapeutic efficacy against colitis.
In vivo studies demonstrated that HESIAA showed enhanced therapeutic efficacy against colitis compared to IAANa under consistent IAA administration, by upregulating anti-inflammatory cytokines (IL-10 and IL-22), downregulating pro-inflammatory mediators (IL-1β, IL-6, and IFN-γ), and reinforcing intestinal barrier integ...