Author

Qian-Jin Lu

2 papers indexed here

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Open access Oct 2026

Targeting the HPGDS-PGD2 axis to treat Th17 cell-mediated autoimmunity in multiple sclerosis

Th17 cells are central drivers of autoimmune pathology, including multiple sclerosis (MS), yet the endogenous metabolic signals that shape their pathogenic differentiation remain incompletely defined. Prostaglandin D₂ (PGD2) is traditionally viewed as an extracellular mediator in allergic diseases. Here, we identify PG...

Yu-Xin Zhuang, Kawai Lei, Yan Li et al. · Signal Transduction and Targ... · 0 citations

Aug 2026

Efficacy of the Bispecific Anti-BAFF/IL-21 Antibody CZ105 Bis2 in Models of Systemic Lupus Erythematosus.

BACKGROUND Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease. B cells play a crucial role in disease initiation and progression. Clinical trial evidence suggests that intensified B-cell depletion can improve SLE therapeutic outcomes. While efficacy and tolerability of belimumab, the first B-cell-ta...

Xiwei Feng, Di Long, Huiqi Yin et al. · Arthritis & Rheumatology · 0 citations