Metal-organic framework-based Z-scheme heterostructure enables oxygen-independent sonodynamic immunotherapy through tumor-associated macrophage reprogramming.
Sonodynamic therapy (SDT) provides spatially controlled tumor treatment, but its efficacy in hypoxic tumors is limited by oxygen-dependent reactive oxygen species (ROS) generation and tumor-associated macrophage (TAM)-mediated immunosuppression. Here, we developed a hyaluronic acid (HA)-modified, metal-organic framewor...