Qian-Qian Wang

Paeoniflorigenone triggers TRIM28 phosphorylation-dependent ferroptosis and immune activation to suppress intrahepatic cholangiocarcinoma.

Intrahepatic cholangiocarcinoma is a highly lethal malignancy characterized by a rising incidence and a dismal 5-year survival rate of <10%. While targeted therapies and immunotherapies have expanded treatment paradigms, their clinical efficacy remains hampered by modest patient response rates. Here, we identify total...