Author

Qian-Ru Zeng

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Review Open access Oct 2026

Mitochondria-associated ferroptosis in ischemic stroke: Pathophysiological evolution, interorganelle crosstalk, and therapeutic targeting.

Ischemic stroke (IS) results from an acute interruption of cerebral blood flow and the ensuing collapse of energy metabolism. Although vascular recanalization can salvage the ischemic penumbra, its overall benefit remains constrained by a narrow therapeutic window and reperfusion injury. Ferroptosis, an iron-dependent...

Meng-Ge Zhang, Yu-Zhe Cai, Qian-Ru Zeng et al. · Pharmacological Research · 0 citations

Open access Oct 2026

Discovery of metabolite biomarkers for cerebral ischemia-reperfusion injury based on metabolomics: neurotoxic mechanism and functional validation of a flavopiridol -related metabolite

To investigate the role and potential mechanism of metabolite alterations during cerebral ischemia-reperfusion injury (CIRI) and to explore novel candidate molecular markers for the diagnosis of this disease. A rat model of middle cerebral artery occlusion was established using the modified Longa EZ intralum...

Zhi-Guang Song, Yu-Chen Liu, Zhen-Lin Zhong et al. · Frontiers in Molecular Biosc... · 0 citations