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Open access Oct 2026

Kurarinol A from Sophora flavescens suppresses hepatic stellate cell activation via the TLR4/MyD88/NF-κB pathway

Sophora flavescens is traditionally used in TCM and Miao/Mongolian/Yi ethnomedicines for hepatobiliary disorders, yet its bioactive flavonoid constituents and mechanisms remain incompletely understood. This study investigated the anti-hepatic fibrosis efficacy, mechanism, and target of the ethyl acetate fraction...

Xing-Jun Chen, Qian Wang, Mu-Zhen Wang et al. · 0 citations
Open access Sep 2026

Ent-abietane diterpenoid Enantiomers from Euphorbia helioscopia inhibits liver fibrosis via suppressing the TGF-β1/smad pathway

Mechanistic investigations revealed that the anti-fibrotic action of 1b in hepatic cells is probably mediated through the TGF-β/Smad signaling cascade, and position abietane-type diterpenoids as prospective molecular structures for the innovation of new therapeutics against liver fibrosis.

Li Jiang, Qian Wang, Jun-Yan Ran et al. · 0 citations
Jul 2026

Hepatoprotective effects of Persicaria capitata against alcoholic liver injury by regulating the gut-liver axis via PI3K-Akt and TLR4/NF-κB signaling pathways.

A mechanistic rationale for the traditional use of P. capitata in treating jaundice and inflammatory conditions is provided and its development as a promising intervention for alcoholic liver-related pathologies is supported.

Lu Hu, Jin Li, Ya-Xin Yang et al. · 0 citations

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