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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Qian Wu

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Open access Oct 2026

Single-cell CRISPR screen maps epigenetic regulators of lineage specification and malignancies in human HSPCs.

Mapping how genetic perturbations influence cell fate is key to understanding human development and disease. Here, we developed a massively parallel single-cell CRISPR (scCRISPR) screening platform in primary human hematopoietic stem and progenitor cells (HSPCs), profiling 322 regulators across 172,382 single-perturbed...

Shi-Ru Yuan, Shang-Da Yang, Yao-Jin Huang et al. · 0 citations

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