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Author

Qian Xu

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2 papers indexed here

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Open access Sep 2026

Hyperglycemia‐Induced Microglial CTSS Disrupts Blood‐Retinal Barrier Integrity via PAR2‐Dependent Downregulation of Endothelial MFSD2A

ABSTRACT Background Diabetic retinopathy (DR), a leading cause of blindness in diabetes, involves dysregulated neuroimmune crosstalk. While microglial activation and endothelial dysfunction are established in DR, the molecular mechanisms linking innate immunity to blood‐retinal barrier (BRB) breakdown remain elusive. M...

Cheng-Ye Xu, Hong-Xue Li, Qian Xu et al. · 0 citations
Open access Aug 2026

Targeting NIK-mediated microglial polarization: a novel therapeutic strategy for diabetic retinopathy

Diabetic retinopathy (DR) is a sight-threatening microvascular complication characterized by blood-retina barrier (BRB) disruption. While inflammation is central to early DR, the role of the non-canonical NF-κB pathway remains poorly understood. We established a murine DR model and performed RNA-seq. Retin...

Hong-Xue Li, Qian Xu, Cheng-Ye Xu et al. · 1 citation · ⚡1

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