Qian-Yu Lu

CRISPR screen reveals FTO-mediated m6A modification of ATF3 as protective in ischaemic stroke.

RNA modifications, especially N6-methyladenosine (m6A), have emerged as pivotal regulators of gene expression in neurological disorders, yet their roles in ischaemic stroke remain unclear. Here, we performed a CRISPR-Cas9 loss-of-function screen targeting 118 RNA modification-related genes in neuronal cells subjected t...