Flavokawain A inhibits high glucose-induced malignant progression of lung cancer cells by suppressing PRMT5-mediated PTEN neddylation and nuclear translocation
A high-glucose microenvironment is a key feature of tumor metabolic reprogramming that promotes lung cancer cell progression. Previous studies have revealed that protein arginine methyltransferase 5 (PRMT5) is overactivated in various cancers and regulates neddylation of the tumor suppressor phosphatase and tensin homo...