The SARS-CoV-2 S2′-helix compared to stem helix confers higher genetic barrier to antibody resistance
It is demonstrated that the S2′-helix in SARS-CoV-2 possesses a higher genetic barrier to antibody resistance than the stem helix, and combination therapy with S2′-helix-targeting antibodies synergistically suppressed the emergence of escape mutants selected by stem helix-directed antibodies.