Dietary Flavonoid Hyperoside Ameliorates High-Fat Diet-Induced Type 2 Diabetes Mellitus by Enhancing Brown Adipose Tissue Thermogenesis, White Adipose Tissue Browning, and Gut Microbiota Remodeling.
Hyperoside, a natural dietary flavonoid widely found in a variety of fruits, vegetables, and medicinal plants, exhibits hypoglycemic as well as hepatorenal protective activities. However, its effects on type 2 diabetes mellitus (T2DM) and the underlying mechanisms remain poorly understood. In this study, T2DM mice were...