The glymphatic system, a cerebral waste clearance pathway identified over a decade ago, has reshaped understanding of Alzheimer’s disease (AD) pathogenesis by linking impaired brain homeostasis to amyloid-β and tau accumulation. This review synthesizes the biological mechanisms governing glymphatic function, including...
Jun-Yu Chen, Wen-Bo Zhang, Qiang Liu et al.· Frontiers in Immunology· 0 citations
The classical view of central nervous system (CNS) immune privilege has evolved from isolation to regulated crosstalk. Perivascular cerebrospinal fluid-interstitial fluid transport and meningeal lymphatic vessels (mLVs) move brain-derived molecules toward immune-rich border tissues and cervical lymph nodes, where antig...
Wan-Ying Li, Yu-Ying Liang, Li-Wei Li et al.· Frontiers in Immunology· 0 citations
A homemade device is used to investigate the effect of STN-DBS on neuroprotection and chronic neuroinflammation in a unilateral 6-hydroxydopamine (6-OHDA)-induced PD rat model and highlights that it is capable of inhibiting NF-κB, modulating glial phenotypes, mitigating neuro inflammation, and ultimately ameliorating p...
Ying Yuan, Qi-Dan Liu, Peng Liu et al.· Frontiers in Immunology· 0 citations
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