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Open access Sep 2026

Application of Targeted Therapies and Response Heterogeneity in Two Children With T‐Cell Acute Lymphoblastic Leukemia With BCL11B::TLX3 Fusion Genes

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy that predominantly affects adolescents and young adults, accounting for approximately 15% of all childhood leukemias [ 1, 2 ]. It is characterized by the malignant transformation of T-cell precursors leading to aberrant proliferation. T...

Qiang Yao, Xiao-Yong Chen, Mei-Zhu Luo et al. · 0 citations
Open access Sep 2026

Genomic Characterization of ETV6::RUNX1‐Positive Childhood B‐ALL in a Chinese Cohort: Novel Fusion Partners, Co‐Occurring Mutations, and Risk‐Stratifying Biomarkers

ETV6::RUNX1 is the most common genetic abnormality in pediatric B‐cell acute lymphoblastic leukemia (ALL; ∼25%), yet the comprehensive genetic architecture and molecular predictors of intermediate‐risk (IR) stratification remain incompletely characterized.

Hua-Lei Luo, Gui-Chi Zhou, Qian Li et al. · 0 citations

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