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Open access Sep 2026

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Liver fibrosis and its terminal stage, cirrhosis, represent a major cause of morbidity and mortality related to hepatic pathologies. Activated hepatic stellate cells (aHSCs) are the principal drivers of fibrogenesis and therefore constitute key therapeutic targets. Lanifibranor, a pan‐peroxisome proliferator‐activated...

Yi-Nuo Yang, Meng-Yao Mu, Ke Ren et al. · 0 citations
Open access Oct 2026

Integrative analysis reveals gut microbiota-associated host regulatory networks in liver fibrosis

Gut microbiota-derived metabolites may contribute to liver fibrosis by affecting host inflammatory, metabolic, and epigenetic pathways. We aimed to identify microbiota-associated host genes shared across liver fibrosis of different etiologies. Microbiota- and metabolite-associated host genes were obtained fr...

Shi-Yu Peng, Ying-Ying Nie, Yu-Zhu Song et al. · 0 citations

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