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Review Sep 2026

Predictive Value of Neutrophil-to-Lymphocyte Ratio (NLR) for Amputation in Patients with Diabetic Foot Ulcer: A Meta-Analysis.

Diabetic foot ulcers frequently lead to amputation, and early risk identification remains challenging. Although the neutrophil-to-lymphocyte ratio (NLR) may predict amputation risk, supporting evidence remains limited. This study evaluated the association between NLR and amputation risk in patients with diabetic foot (...

Rui-Bin Feng, Cairui Chen, Qi-Kai Hua · 0 citations
Open access Sep 2026

Integrating bulk and single-cell RNA sequencing identifies and validates lipid metabolism-associated genes in diabetic foot ulcer

This study identifies a DFU-associated macrophage program centered on Pro-inflammatory macrophages and characterized by inflammatory activation, lipid-associated gene-signature activity, and inferred endothelial communication.

Xia-Sui Peng, Wen-Qiang Wang, Qi-Kai Hua et al. · 0 citations
Open access Jul 2026

Indolicidin‐Decorated Photosensitizer for Enhanced Antibacterials and Accelerated Diabetic Wound Healing

This PTBT/Indolicidin‐based thermosensitive hydrogel effectively eliminated resistant bacteria, mitigated inflammation, stimulated angiogenesis, and accelerated healing of infected diabetic wounds, offering a safe, controllable, and translationally promising therapeutic strategy.

Xiang Chen, Zhanming Lin, Yong-Jun Mo et al. · 1 citation

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