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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Qin-Hai Ma

h-index 19 View on Semantic Scholar

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Open access Sep 2026

Subcutaneous immunization with replication-competent live influenza virus confers durable protective immunity without respiratory pathology in mice.

Current influenza vaccination strategies are constrained by the trade-off between the safety of inactivated platforms and the immunogenic potency of live attenuated vaccines. Here, we provide a comprehensive demonstration that subcutaneous (SC) immunization with a non-attenuated, replication-competent live influenza A...

Zhou-Lang Wang, Cheng-Xing Zhou, Li-Xin Yin et al. · 0 citations
Open access Jul 2026

Structure-Based Design of New Nonpeptidic Covalent Mpro Inhibitors against SARS-CoV-2 and Omicron Variants

The main protease (Mpro) is a prime target for anti-SARS-CoV-2 drugs. Herein, we describe the structure-based covalent modifications that generate new nonpeptidic covalent Mpro inhibitors. The compounds exhibit strong inhibition against Mpro at submicromolar levels. The deuterated lead compound exhibits submicromolar...

Honglei Bao, Ling-Chen Sun, Shilin Gong et al. · 0 citations

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