A Health-Protective Screening Threshold for Personal Care Products: Metabolomic and Endocrine Mechanisms of Adolescent Reproductive Toxicity in Zebrafish.
Adolescents are uniquely vulnerable to endocrine-disrupting chemicals (EDCs) due to the critical maturation of the hypothalamic-pituitary-gonadal (HPG) axis, yet current safety assessments overlook whole-formulation risks during this developmental window. Using an adolescent zebrafish model, we established a biological...