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Open access Oct 2026

A “Progenitor Cell Ark” hydrogel system for intervertebral disc regeneration via mitochondrial targeting and mitophagy enhancement

Intervertebral disc degeneration (IVDD), driven by progenitor cell loss and oxidative stress, remains a major clinical challenge with limited effective regenerative therapies. Here, we present a “Progenitor Cell Ark,” a triple-layered hydrogel microsphere system designed for synergistic cell delivery and microenvironme...

Yi-Lin Yang, Yi-Xue Huang, Hao Liu et al. · 0 citations
Jul 2026

Bioinspired Hydrogel Remodels the Niche after Spinal Cord Injury for Neural Reconnection by Promoting Angiogenesis and Reducing Inflammation.

Spinal cord injury (SCI) disrupts the local microenvironmental niche, resulting in persistent neuroinflammation, vascular dysfunction, and impaired neuronal regeneration, presenting a significant challenge for tissue repair. In this context, hydrogels offer a versatile strategy for targeted and sustained therapeutic de...

Haifei Cao, Yicheng Ding, Xingzhi Liu et al. · 0 citations

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