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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Qin-Yang He

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Oct 2026

Development of Potent and Selective EGFR-PROTACs Based on Macrocyclic Fourth-Generation EGFR Inhibitors

Epidermal growth factor receptor (EGFR) mutant-driven non-small cell lung cancer (NSCLC) frequently develops acquired resistance to third-generation tyrosine kinase inhibitors (TKIs), particularly through the EGFR C797S mutation. Existing EGFR-targeting proteolysis-targeting chimeras (PROTACs) remain limited by unfav...

Qin-Yang He, Yan Cheng, Qing Zhang et al. · 0 citations

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