Author

Qin-Yong Ye

2 papers indexed here

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Open access Sep 2026

Neurotoxicity of PM2.5-Bound Multi-Pollutant Mixtures in Parkinson’s Disease: Exploring the INPP5D/SHIP1-PI3K-AKT Axis via an Integrative Multi-Omics Study

The multi-omics and in vitro findings raise a plausible mechanistic hypothesis that NIST SRM 1648a-mimicked PM2.5-related pollutant mixtures may exacerbate PD-like neuronal injury through the SHIP1/PI3K-AKT signaling axis.

Lu-Fei Chen, Chao-Xian Dai, Zhen-Fang Wu et al. · Journal of Xenobiotics · 0 citations

Aug 2026

EAAT1 sustains redox homeostasis and temozolomide resistance through glutamate-dependent regulation of the Keap1/Nrf2 axis in glioblastoma.

Glioblastoma (GBM) exhibits profound metabolic and redox adaptation that supports tumor progression and therapeutic resistance. Here, we identify the glutamate transporter EAAT1 (SLC1A3) as a critical regulator of glutamate-dependent redox homeostasis in GBM. Analysis of TCGA and CGGA datasets showed that EAAT1 express...

Lu-Fei Chen, Ru-Ying Lin, Yong-Pei Xu et al. · Experimental Neurology · 0 citations