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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Qing-Chao Liu

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Aug 2026

Design and synthesis of the first PARP1 and PRMT5 dual inhibitors for the treatment of breast cancer.

Poly(ADP-ribose) polymerase 1 (PARP1) is a key factor responsible for repairing DNA single-strand breaks and maintaining genomic stability. PARP1 inhibitors have achieved remarkable therapeutic efficacy in the treatment of BRCA-mutant breast cancer. However, only a small proportion of breast cancer patients carry BRCA...

Ying Xu, Qian Lei, Shuguang Yang et al. · 0 citations

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