Rational Design of Novel Tetrazolinone-Pyrazine Derivatives: Synthesis, Antifungal Activity, and Mechanism of Action
G143A mutation-driven target-site resistance severely impairs the field efficacy of traditional Quinone outside inhibitors (QoIs). To solve this agricultural crisis, novel tetrazolinone-pyrazine derivatives were rationally designed and synthesized by integrating potentially resistance-breaking tetrazolinone toxophore...