Author

Qing-Ping Shi

3 papers indexed here

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Review Open access Aug 2026

Lactate as a Master Regulator of Immune Suppression: From Metabolic Waste to Epigenetic Checkpoint in Colorectal Cancer

Colorectal cancer, especially the microsatellite-stable subtype, which accounts for 85% to 95% of cases, resists immune checkpoint inhibitors largely due to metabolic reprogramming in the tumor microenvironment. Lactate has evolved from a waste product into a central immunosuppressive regulator. Oncogenic KRAS and BRAF...

Bei-Yan Chen, Shuang Gao, Xin Chen et al. · International Journal of Mol... · 0 citations

Open access Sep 2026

Integrated Metabolic and Immune Molecular Subtyping and a Molecular Classification Score for Revealing Disease Heterogeneity in Pulmonary Arterial Hypertension

MIRS provides a molecular stratification basis for subtype discrimination and a hypothesis-generating framework for future therapeutic investigations and failed to discriminate PAH from controls in PBMCs, indicating that this tissue-derived signature is not readily detectable in peripheral blood.

Xin Chen, Yue-Tong Zhu, Qing-Ping Shi et al. · Metabolites · 0 citations

Open access Aug 2026

Exploring the Molecular Mechanism of Cinnamaldehyde Intervening in Ochratoxin A-Induced Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease Comorbidity: An Integrated Approach Based on Network Pharmacology, Network Toxicology and Molecular Docking

Background/Objective: Cinnamaldehyde (CA) is a naturally occurring bioactive compound derived from the leaves, bark, roots, and flowers of the Chinese medicinal plant Cinnamomum cassia. It exhibits a broad spectrum of pharmacological properties, encompassing antioxidant, antibacterial, anti-diabetic, antifungal, and an...

Ming-Li Shen, Qing-Ping Shi, Shuang Gao et al. · Pharmaceuticals · 0 citations