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Author

Qing-Qing Cai

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Open access Oct 2026

Improved efficacy of Orelabrutinib plus Rituximab, Temozolomide and High-Dose Methotrexate (RMOT) vs. RMT in untreated primary CNS lymphoma: A matched analysis

Primary central nervous system lymphoma (PCNSL) is a rare, aggressive malignant tumor with poor prognosis, and the optimal standard treatment remains undefined. This study aimed to compare the efficacy and safety of rituximab, high-dose methotrexate plus temozolomide (RMT regimen) and orelabrutinib plus RMT (RMOT...

Peng Zhang, Man Nie, Hang Yang et al. · 0 citations
Review Open access Jul 2026

Mechanisms, optimization strategies, and salvage options for CAR-T cell therapy

A conceptual “Why-How-What if” framework to navigate the complexities of treatment failure is proposed, integrating mechanisms of failure with evolving optimization and salvage strategies, which provides a practical roadmap for clinical and translational progress.

Bi-Jing Wu, Jia-Hui Wang, Qihua Zou et al. · 0 citations

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