Neurodegenerative diseases are characterized by progressive protein aggregation, mitochondrial dysfunction, neuroinflammation, and cognitive decline, yet effective mechanism‐based interventions remain limited. Sirtuin 1 (SIRT1), an NAD+‐dependent deacetylase, has emerged as a multifunctional regulator linking stress ad...
Jia-Bin Duan, Jia-Qiang Liu, Qing-Sheng Meng et al.· The FASEB Journal· 0 citations
The integration of sophisticated pharmacological agents with circuit‐level neuromodulation represents the next frontier in treating cholinergic dysfunction across the spectrum of neurodegenerative disorders, advancing the therapeutic goal from chemical enhancement to circuit repair and regeneration.
Lei Lei, Xiao-Yun Hu, Rui-Da Lu et al.· CNS Neuroscience & Therapeut...· 0 citations
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