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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Qing-Wang Chen

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Open access Aug 2026

Distinct multi-omics signatures of clinical subgroups of type 2 diabetes define heterogeneous responses to an insulin sensitizer

Type 2 diabetes (T2D) subgroups defined by clinical variables differ in disease progression and treatment response. To uncover potential molecular drivers of this heterogeneity, we performed a multi-omics analysis of 826 drug-naïve T2D patients from two phase 3 trials of the insulin sensitizer chiglitazar. Here we show...

Ze-Hui Cao, Ruo-Lan Zhang, Hao-Nan Chen et al. · 0 citations
Open access Aug 2026

Plasma titration provides a physical ruler for cross-platform proteomics

Plasma proteomics is expanding across platforms and cohorts, and integrating these data for AI demands comparability at the protein level, not merely concordant associations1,2. Affinity and MS platforms use distinct probes (antibodies, aptamers, or peptides) and signal readouts, yielding contradictory cross-platform r...

Yaqing Liu, Haiyan Wang, Yutong Zhang et al. · 0 citations
Open access Aug 2026

Benchmarking RNA-seq with the Quartet and MAQC reference materials to establish best practices for accurate alternative splicing analysis

It is shown that high data quality and depth improved the accuracy of splice junction detection, as well as isoform- and event-level quantification and differential analysis, contributing to effective srRNA-seq application in RNA splicing research.

Duo Wang, Jia-Xin Zhao, Qing-Wang Chen et al. · 0 citations

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