SIRT1-mediated deacetylation of Lysyl-tRNA synthetase reprograms lipid metabolism to promote colorectal tumorigenesis
Aminoacyl-tRNA synthetases (AARSs) have long been recognized for their canonical role in protein synthesis, catalyzing the attachment of amino acids to their cognate tRNAs. However, accumulating evidence has revealed that many AARSs also exert non-canonical functions under various physiological and pathological con...