Open access
Jul 2026
Discovery of spirocyclic amide scaffolds as novel neddylation E1 inhibitors to suppress the growth and survival of lung cancer cells.
Compound 24 (HA-218-6-31-80) represents a promising NAE inhibitor, offering a potential therapeutic candidate for lung cancer and a novel scaffold for neddylation targeted drug discovery.
Qiuxun Chen, Jiezhen Zhuo, Changxin Zhong et al.
· RSC Medicinal Chemistry · 0 citations