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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Qing-Zhen Hou

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Open access Oct 2026

Protein Language Models Identify Early Folding Residues as Critical Hotspots for Pathogenic Variants and Cancer Prognosis

Identifying the specific residues that initiate protein folding is critical for understanding protein stability and the mechanisms of misfolding-related diseases. However, the systematic, proteome-wide identification of these early folding residues (EFRs) has been hampered by both experimental and computational limitat...

Li-Sha Guo, Fu-Chong Yuan, Na Zhou et al. · 0 citations
Open access Aug 2026

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

ProMetNet is presented, a biochemically constrained framework that incorporates pathway‐derived connectivity from the Reactome database into neural network architecture that consistently outperforms evaluated multi‐omics integration methods, maintaining high discriminative performance under substantial data downsamplin...

Ming-Hui Zhao, Na Zhou, Ruo-Tong Liu et al. · 0 citations

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