T-2 Toxin Disrupts Alzheimer's-relevant App/Tau Homeostasis via Circadian-p53-Senescence Crosstalk: Evidence from Human Neuroblastoma Cells.
Environmental mycotoxins are pervasive exposures, yet how they perturb Alzheimer's disease (AD)-relevant proteostasis remains unclear. We treated SH-SY5Y cells with low-dose T-2 toxin (6nM) for 24h, and profiled AD-relevant protein changes alongside transcriptomic, circadian, and senescence-related readouts. We report...