Qiong-Lian Huang

Beyond the membrane: lipid rafts and oxysterols establish cholesterol as a dynamic signaling hub while underlying the cholesterol paradox in cancer.

Metabolic reprogramming of cholesterol extends beyond its canonical role in membrane biogenesis, serving as a dynamic signaling hub that facilitates tumor progression and therapy resistance. In cancer therapy, the limited clinical efficacy and variable outcomes of non-selective lipid-lowering interventions, such as sta...